This term paper focus to discuss on Decision Support system. A decision support system (DSS) can be a computer program application in which analyzes business data and presents it making sure that users can make business decisions with less effort. A decision support method may present information graphically and may even include an expert method or artificial intelligence. It could be aimed at business executives or some other group of knowledge employees. Here also briefly analysis on DSS Characteristics and capabilities, Development Frameworks and Clinical decision support system.