Main purpose of this lecture is to presentation on Prediction of Protein Structure. Structure prediction tries to create models of 3D structures of proteins that is useful for understanding structure-function associations. The protein folding problems, like, The information for 3D images structures is coded within the protein sequence. Proteins fold within their native structure in mere seconds. Native structures are both thermodynamically stables and kinetically available etc. This lecture briefly explain Prediction of Protein Structure with examples and pictures.