The aim of this study is to present on Fungal Disease Coccidioidomycosis. Coccidioidomycosis is an infection of the lungs caused by inhaling spores of the fungus Coccidioides immitis. It is a fungus found in the soil of dry, low rainfall areas. Like the other true-pathogenic, systemic human fungal diseases histoplasmosis, blastomycosis, and paracoccidioidomycosis, Coccidioidomycosis starts out as a lung disease caused by inhalation of the conidia. The diagnosis depends on the stage of infection. Skin biopsy is a common test for this disease.