The aim of this lecture is to present on Fall of Roman Empire. In 476 C.E. Romulus, the last of the Roman emperors in the west, was overthrown by the Germanic leader Odoacer, who became the first Barbarian to rule in Rome. The fall of the Roman empire traditionally marks the end of the period of Antiquity. This lecture briefly describe some causes of Roman Empire Fall: West had longer barbarian frontier; Persians civilized and signed treaties; East had money to pay off invaders; Eastern boundaries easier to defend and Constantinople a fortress city.