Astronauts Successfully Conduct First CRISPR Genetic Editing in Space

Long stains cut in unnecessary situations in space can have some pretty unwanted effects on the body.

Even the short-term relative protection of the International Space Station, unpacked with the risks of cancer and heart disease, muscle loss and many more long-term risks (as many space agencies expect one day to do) must have a variety of negative effects on expatriates. . One of the biggest risks is the intense radiation in space. Radiation in DNA splits creates dangerous areas of damage as absolutely bright, double-stranded breaks. As the body repairs itself with two specific paths, a lot of complications can occur, and this is the process by which DNA conversion occurs.

Now, in an attempt to study how astronauts’ DNA is damaged and repaired, scientists have demonstrated the first case of CRISPR technology being fully used in space. The incredible feat was conducted on yeast cells and allowed scientists to pay unprecedented attention to selected DNA repair pathways under space conditions, which were previously impossible due to safety barriers. The results were published in PLOS One Journal. Senior author Sebastian Kraves said in a statement, “While the team has successfully deployed innovative technologies such as CRISPR genome editing, PCR and nanopore sequencing in the final environment, we have been able to integrate them into a functionally complete biotechnology workflow applicable to DNA repair and other studies.”

Astronauts Successfully Conduct First CRISPR Genetic Editing in Space

“These developments will fill this team with the hope of exploring the vast expanse of space and finding a renewal of humanity for habitation.” While CRISPR has had an effective effect in recent years on targeting and modifying specific regions of DNA, it is important to delete any sequence inserted. This capability makes it a suitable tool for inducing double-stuck brakes under space-controlled conditions.

Previous attempts to involve irrational technology using radioactivity have indiscriminately damaged DNA, making the path to repair incredibly difficult. Using CRISPR, scientists can take some breaks and follow how cells choose to repair the damage. The experiment was created by Sarah Stahl-Rommel and colleagues in the space genes, who called on students around the world to compete to perform their experiments in space.