Chemoreceptor is a sensory nerve cell or sense organ, as of smell or taste that responds to chemical stimuli. It is usually refers to those which influence the respiratory and cardiovascular control centres in the brain stem: the medullary chemoreceptors, sensitive to pH changes in the cerebral extracellular fluid, and the arterial chemoreceptors which continually sense and respond to changes mainly in blood oxygen, carbon dioxide and pH, leading to appropriate reflex adjustments via afferent nerves to the brain stem control centres.

Chemoreception relies on chemicals that act as signals to regulate cell function, without the chemical necessarily being taken into the cell for metabolic purposes. While many chemicals, such as hormones and neurotransmitters, occur within organisms and serve to regulate specific physiological activities, chemicals in the external environment are also perceived by and elicit responses from whole organisms.

In more general terms, a chemosensor detects toxic or hazardous chemicals in the internal or external environment of the human body (e.x. chemotherapy) and transmits that information to the central nervous system, and rarely the peripheral nervous system, in order to expel the biologically active toxins from the blood, and prevent further consumption of alcohol and/or other acutely toxic recreational intoxicants.


Receptors of Chemoreceptor

The cells in our bodies that are specifically designed for sensing have receptors on their membranes, the outside boundary of the cell. These receptors act like little fingers that grab things around them and then in turn tell our brain what they found; even if it is sensing a smell we would rather not smell.

Receptors are designed to detect specific molecules called ligands. But they’re picky and the key word here is ‘specific’. Each ligand will only fit into the receptor that’s specifically designed to detect it, and receptors will only convey messages about that ligand. This specificity is called a lock and key fit because only the ligand for a receptor can trigger a reaction. The main chemoreceptors involved in respiratory feedback are:

Central Chemoreceptors: These are located on the ventrolateral surface of medulla oblongata and detect changes in the pH of spinal fluid. They can be desensitized over time from chronic hypoxia (oxygen deficiency) and increased carbon dioxide.

Peripheral Chemoreceptors: These include the aortic body, which detects changes in blood oxygen and carbon dioxide, but not pH, and the carotid body which detects all three. They do not desensitize, and have less of an impact on the respiratory rate compared to the central chemoreceptors.


Control of Breathing

Particular chemoreceptors, called ASICs, detect the levels of carbon dioxide in the blood. To do this, they monitor the concentration of hydrogen ions in the blood, which decrease the pH of the blood. This can be a direct consequence of an increase in carbon dioxide concentration, because aqueous carbon dioxide in the presence of carbonic anhydrase reacts to form a proton and a bicarbonate ion.

Chemoreceptors that regulate the depth and rhythm of breathing are broken down into two categories.

Central Chemoreceptors are located on the ventrolateral surface of medulla oblongata and detect changes in pH of cerebrospinal fluid. They have also been shown experimentally to respond to hypercapnic hypoxia (elevated CO2, decreased O2), and eventually desensitize. These are sensitive to pH and CO2.

Peripheral Chemoreceptors: consists of aortic and carotid bodies. Aortic body detects changes in blood oxygen and carbon dioxide, but not pH, while carotid body detects all three. They do not desensitize. Their effect on breathing rate is less than that of the central chemoreceptors.

Chemoreceptors are also found in our hearts and heads. If we have ever felt ‘short of breath’ because of exercise or nervousness, the chemoreceptors in our body have detected that oxygen levels are too low or that carbon dioxide levels are too high.


Reference: Wikipedia,,