Bioresponsive Hydrogels in DDS

Bioresponsive hydrogels, which undergo structural and/or morphological changes in response to a biological stimulus, have been investigated for numerous applications in drug delivery, tissue regeneration, biosensors, and biomimetic systems. This system works as a feedback loop upon release of insulin the sugar levels drop, resulting in a pH increase that stops the release of further insulin.In the presence of collagenase the peptide cross-linked hydrogels were successfully degraded in dependence on the concentration of the enzyme and the initial cross-linking density.