This article focus to Define and Discuss on Numerical Differentiation. Here explain Numerical Differentiation with mathematical examples and graph. Numerical differentiation may be the process of finding derivatives numerically for the function whose values get in data form made from an experiment. For evenly distributed data points and when we need the type at data points organic meat use the derivative formulations called finite differences. If the data points are not just or required derivatives are at points other than data points, we may make use of interpolating polynomials.