Basic purpose of this presentation is to explain the Case of the Sassy Blistering Woman. Blisters started out on each heel, then progressed in the legs, and then spread the hands. Started while red spots, progressed to be able to blisters and painful humps. Blisters began 3 days and nights after patient started furosemide for ankle edema. Cold-like indicators occurred shortly before very first blisters appeared. Here also explain differential diagnosis, named: Acute febrile neutrophilic dermatosis, Pyoderma gangrenosum, Cutaneous malignancyetc. And also explain on Infection secondary to immunosuppresion.