Principle objective of this lecture is to presentation on Anti Diabetic Drugs. Diabetic is a disease caused by elevated glucose levels. Other major causes are body does not produce enough insulin and cells do not respond to the insulin that is produced. Here briefly discuss on some powerful Anti Diabetic Drugs, they are Sulfonylureas, Meglitinides, Biguanides, Thiazolidinediones and α-glucosidase inhibitor. Finally discuss on Mechanism of Action of Anti Diabetic Drugs.